ONCOLOGY
POTARBIN®

Film-coated tablets
Pharmacotherapy group:
Antitumor agents; protein kinase inhibitors; other protein kinase inhibitors
INN:
pazopanib
Dosages:
200 mg; 400 mg
Available on a doctor's
prescription
What is the drug POTARBIN®
POTARBIN® is a powerful inhibitor of many tyrosine
kinases for oral administration, including tyrosine kinases of vascular
endothelial growth factor (VEGFR) -1, -2, -3 receptors; platelet growth factor
(PDGFR)receptors-α and-β;
fibroblast growth factor (FGFR) receptors -1 and -3; stem cell factor receptor
(Kit), as well as interleukin 2-induced T-cell kinase(Itk); leukocyte-specific
proteintyrosine kinase (Lck) and macrophage colony stimulating factor receptor tyrosine
kinase (c-Fms).
Dosage form
Dosage 200 mg: Round biconvex tablets, covered with a film-coated pink color with a brownish tinge. The core of the tablet is white to almost white in color.
Dosage 400 mg: Round biconvex tablets coated with a white film coating. The
core of the tablet is white to almost white in color.
Indications for use
Treatment of advanced renal cell carcinoma (RCC).
Treatment of advanced soft tissue sarcoma (SMT) (excluding gastrointestinal
stromal tumors and liposarcoma) in patients who have previously received
chemotherapy.
Efficacy and safety studies
In accordance with current legislation, the drug has proven its effectiveness, safety and quality during state registration. For registration purposes, a bioequivalence study was conducted with the original (reference) medicinal product.